Bionano Genomics Announces Publication of Comprehensive Validation of Optical Genome Mapping for Hematologic Neoplasms
Key findings from evaluation of 59 Heme Samples and 10 Controls:
OGM detected 162/164 SVs detected by standard cytogenetics methods of karyotyping and FISH
OGM detected chromosomal aberrations missed by karyotyping and FISH in 35 cases
OGM Sensitivity: 98.7%
OGM Specificity: 100%
Positive Predictive Value: 100%
Negative Predictive Value: 98%
OGM Accuracy: 99.2%
First-Pass Success Rate: 100%
Limit of Detection (LOD) for aneuploidies, translocations, interstitial deletions and duplications at 400X: 5% variant allele fraction
Key findings from evaluation of 59 Heme Samples and 10 Controls:
?OGM detected 162/164 SVs detected by standard cytogenetics methods of karyotyping and FISH
?OGM detected chromosomal aberrations missed by karyotyping and FISH in 35 cases
?OGM Sensitivity: 98.7%
?OGM Specificity: 100%
?Positive Predictive Value: 100%
?Negative Predictive Value: 98%
?OGM Accuracy: 99.2%
?First-Pass Success Rate: 100%
?Limit of Detection (LOD) for aneuploidies, translocations, interstitial deletions and duplications at 400X: 5% variant allele fraction
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